Time: 3 February 2017, 14:00<\/p>\n
Place: Department of Nutrition, Exercise and Sports, Aud 1, August Krogh Building, Universitetsparken 13, 2100 Copenhagen<\/p>\n
Opponents:
\nProfessor Anders Sj\u00f6din (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.<\/p>\n
Professor Stuart Egginton, School of Biomedical Sciences, University of Leeds, United Kingdom.<\/p>\n
Professor J\u00f8rgen Jensen, Department of Physical Performance, Norwegian School of Sport Science, Norway.<\/p>\n
Supervisor:
\nProfessor Ylva Hellsten, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark<\/p>\n
About the PhD thesis:
\nOne of the major causes of type 2 diabetes is a weakened response to insulin (insulin resistance) in the muscles. Individuals with insulin resistance have fewer small blood vessels (capillaries) and less VEGF (a molecule important to the formation of capillaries) in the muscles. It has been proven that exercise is beneficial to the formation of new capillaries (capillarization) and for increasing insulin sensitivity, however people with insulin resistance are less susceptible to these effects.<\/p>\n
In this thesis the effect of an increased capillary density in muscles on whole-body insulin sensitivity was examined. Healthy rats and insulin resistant humans were given a drug known to promote capillarization. In addition, obese Zucker rats (an animal model of insulin resistance) received VEGF augmentation treatment to one muscle in the leg and were subjected to a period of swim training (6 weeks).<\/p>\n
A causal relationship between muscle capillarization and insulin sensitivity is shown in this thesis.<\/p>\n