30 November 2018, 13:00<\/p>\n
Aud 1, August Krogh Building, Universitetsparken 13, 2100 Copenhagen<\/p>\n
Associate professor Nikolai Baastrup Nordsborg (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark<\/p>\n
Assistant professor Dudley Lamming, University of Wisconsin, USA<\/p>\n
Dr. med. Sten Lund, Department of Clinical Medicine, Aarhus University, Denmark<\/p>\n
Associate professor Thomas Elbenhardt Jensen, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark<\/p>\n
Previous studies have shown that a chronic low protein\/high carbohydrate diet (LPHC) is beneficial, whereas a high protein\/low carbohydrate diet (HPLC) is detrimental, to metabolic health and life-span. Periodization, i.e. switching between periods of normal and special diets, is a way to increase adherence but it is not known if the health-benefits of a LPHC diet would be retained on a periodized LPHC diet regimen. Furthermore, the interaction between a periodized LPHC diet regimen and exercise training is unknown. This is important to know since diet and exercise are commonly co-implemented to promote health.<\/p>\n
This PhD project investigated mainly the efficacy of periodized LPHC diet, provided in 14 day on\/off cycles, to promote metabolic health and its interaction with concurrent voluntary wheel running in mice. A secondary study investigated the effect of a chronic normal, high and low protein diet on skeletal muscle insulin action.<\/p>\n
We found that a periodized LPHC diet regimen transiently conferred potent obesity-protective and insulin-sensitizing benefits, independent of skeletal muscle. Unexpectedly, concurrent exercise dampened some of these benefits, most notably the induction of a key mediator of LPHC actions, FGF21, in the liver. This suggests that a periodized LPHC diet regimen could be an effective health-promoting strategy but that its interaction with exercise warrants consideration.<\/p>\n