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Ph.d.-forsvar — Andreas H. Breenfeldt Andersen is defending his PhD thesis: Detection of blood volume manipulations and the physiological effect hereof. An evaluation of iron biomarkers
Date & Time:
Digital. Meeting URL: https://ucph-ku.zoom.us/j/66744327183.
Department of Nutrition, Exercise and Sports, University of Copenhagen
9 December 2020, 09:00
Digital: To attend the PhD defence, follow the link and hereafter the instructions to download the required Zoom-client.
Meeting URL: https://ucph-ku.zoom.us/j/66744327183.
Associate Professor Lykke Sylow (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
Associate researcher Paul Robach, Ecole Nationale des Sports de Montagne, France.
Senior Clinical Lecturer and Head of biology Nicolas Leuenberger, Swiss Laboratory for Doping Analyses and University of Lausanne, Switzerland.
Associate professor Nikolai Baastrup Nordsborg, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
About the thesis
As prohibited blood manipulations remains a challenge for anti-doping authorities, it is important to continuously investigate and evaluate new potential detection methods.
A current need is to evaluate the potential of the iron regulatory hormones hepcidin and erythroferrone and improve the sensitivity of current detection methodologies following micro-dosing regimes in a sex-specific context as well as evaluate the impact of well-known confounding factors.
In addition, specific and sensitive biomarkers relevant in an anti-doping context may also have merit in a blood donation context, where a rapid recovery after blood donation is a priority. Finally, it is important to determine the physiological effects of the applied regimes to establish the lower limit of relevance for anti-doping authorities.
The present thesis demonstrates that iron regulatory hormones can be of high value both in a clinical setting such as blood banks as well as in an anti-doping context. However, large fluctuations in hepcidin caused by normal variation should be taken into account and limit hepcidin’s applicability in anti-doping, whereas erythroferrone shows promising results.
Future studies should continue the efforts of developing a sensitive detection method for autologous blood transfusion and EPO doping as this thesis demonstrate that both strategies are performance enhancing even in small doses. In addition, the current methodologies are challenged by such micro-dosing strategies evident by either a low sensitivity as well as a compromised specificity in altitude, which is a common situation for elite athletes.