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Seminar — The regulation of metabolic health and longevity by specific dietary macronutrients v/ Assistant Professor Dudley Lamming, University of Wisconsin-Madison, US
Date & Time:
Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
August Krogh Club
29 November 2018
12:30-13:30: Seminar and discussion
13:30-14:30: Post seminar servings and socializing
Calorie restriction (CR), or reducing calorie intake without malnutrition, robustly extends lifespan in model organisms ranging from yeast to mammals. CR restricts the intake of all macronutrients (protein, carbohydrate, and fat), but whether the effects of a CR diet are mediated solely by reduced caloric intake or reduced consumption of specific macronutrients has long been unclear.
Over the last decade, research in organisms including flies and mice has highlighted a critical role for dietary protein in mediating longevity, with reduced consumption of dietary protein promoting longevity and improving metabolic health. However, the specific dietary components altered in a low protein diet that promote health and longevity remain unknown. In this talk, I will discuss ongoing research in my laboratory into the role of the three branched-chain amino acids (BCAAs; leucine, isoleucine, valine) in regulating metabolic health and longevity.
Green CL, Lamming DW. Regulation of metabolic health by essential dietary amino acids. Mech Ageing Dev. 2018, Jul 22; pii: S0047-6374(18)30079-4. doi:10.1016/j.mad.2018.07.004. [Epub ahead of print]. PMID: 30044947 PMCID: In Progress.
Cummings NE, Williams EM, Kasza I, Konon EN, Schaid MD, Schmidt BA, Poudel C, Sherman DS, Yu D, Sebastian I. Arriola Apelo, Cottrell SE, Geiger G, Barnes ME, Wisinski JA, Fenske RJ, Matkowskyj KA, Kimple ME, Alexander CM, Merrins MJ, Lamming DW. Restoration of metabolic health by decreased consumption of branched-chain amino acids. J Physiology, 2018, Feb 15; 596(4):623-645.
Fontana L, Cummings NE, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, Cava E, Spelta F, Tosti V, Syed FA, Baar EL, Veronese N, Cottrell SE, Fenske RJ, Bertozzi B, Brar HK, Pietka T, Bullock AD, Figenshau RS, Andriole GL, Merrins MJ, Alexander CM, Kimple ME, Lamming DW. Decreased consumption of branched chain amino acids improves glycemic control. Cell Reports, 2016; 16(2):520-30.
Dr. Lamming completed his PhD in Experimental Pathology with Dr. David Sinclair at Harvard University in 2008, and then performed postdoctoral research at the Whitehead Institute for Biomedical Research with Dr. David Sabatini. In 2014, he joined the faculty of the University of Wisconsin-Madison, where he is an Assistant Professor of Medicine, and co-directs the UW-Madison Department of Medicine Mouse Metabolic Phenotyping Platform. He has a joint appointment as a Research Health Scientist with the William S. Middleton Memorial Veterans Hospital.
Dr. Lamming is primarily focused on understanding the regulation of aging and metabolism by nutrient signaling pathways, including the mechanistic target of rapamycin (mTOR), and specific dietary macronutrients. His laboratory recently determined that low protein diets promote metabolic health – improving blood sugar control and reducing adiposity – in humans and mice, and identified dietary branched-chain amino acids (BCAA) as key regulators of these effects. His laboratory is now investigating the molecular and physiological mechanisms by which BCAAs regulate metabolic health, and is exploring the possibility that specifically modulating dietary BCAAs can treat or prevent metabolic syndrome, other age-related diseases, and promote longevity and healthspan.